NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing
نویسندگان
چکیده
منابع مشابه
RNA Binding Proteins in the miRNA Pathway
microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miR...
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As you will see, all referees acknowledge that the findings are potentially interesting and suitable for publication in EMBO reports. However, both referees 1 and 2 point out that the observed effect of introns on enhancing mature miR163 levels should be extended to other miRNAs. Both referees also mention the inconsistency between your study and the one from Voinnet's lab regarding the require...
متن کاملThe RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells
The Ewing Sarcoma protein (EWS) is a multifaceted RNA binding protein (RBP) with established roles in transcription, pre-mRNA processing and DNA damage response. By generating high quality EWS–RNA interactome, we uncovered its specific and prevalent interaction with a large subset of primary microRNAs (pri-miRNAs) in mammalian cells. Knockdown of EWS reduced, whereas overexpression enhanced, th...
متن کاملIntrons of plant pri-miRNAs enhance miRNA biogenesis
Plant MIR genes are independent transcription units that encode long primary miRNA precursors, which usually contain introns. For two miRNA genes, MIR163 and MIR161, we show that introns are crucial for the accumulation of proper levels of mature miRNA. Removal of the intron in both cases led to a drop-off in the level of mature miRNAs. We demonstrate that the stimulating effects of the intron ...
متن کاملRegulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region.
Noncoding RNAs (ncRNAs) control cellular programs by affecting protein-coding genes, but evidence increasingly points to their involvement in a network of ncRNA-ncRNA interactions. Here, we show that a long ncRNA, Uc.283+A, controls pri-miRNA processing. Regulation requires complementarity between the lower stem region of the pri-miR-195 transcript and an ultraconserved sequence in Uc.283+A, wh...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2017
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.3455